Duloxetine in the UK: What You Need to Know

If you’ve been told to take duloxetine, also sold as Cymbalta, you probably have questions about dosing, cost and safety. This guide breaks down the basics so you can feel confident about your treatment.

How duloxetine works and who it helps

Duloxetine is a selective serotonin‑noradrenaline reuptake inhibitor (SNRI). It lifts mood by balancing brain chemicals and also eases nerve pain. Doctors in the UK prescribe it for major depression, generalized anxiety disorder, diabetic neuropathy and chronic musculoskeletal pain.

Typical UK dosage and how to take it

Adults usually start with 30 mg once a day, taken with food to avoid stomach upset. After a week or two, the dose may be increased to 60 mg daily, which is the most common maintenance level. Some people need 120 mg split into two doses. Always follow your prescriber’s plan – jumping to a higher dose can raise the risk of side effects.

Take the tablet at the same time each day. If you miss a dose, take it as soon as you remember unless it’s almost time for the next one. Never double up.

Where to get duloxetine legally in the UK

The safest route is a UK NHS prescription. If you have private health cover, you can get it from a private GP or specialist. For those without a prescription, online pharmacies that are registered with the Medicines and Healthcare products Regulatory Agency (MHRA) can dispense it when you provide a valid prescription.

Look for the MHRA logo, a physical address in the UK and a clear privacy policy. Avoid any site that offers to sell duloxetine without a prescription – that’s illegal and risky.

Cost tips: brand vs. generic

Cymbalta is the brand name; it’s usually more expensive than generic duloxetine. A 30‑day supply of generic duloxetine 60 mg can cost between £5 and £15 in most UK pharmacies, while the brand may be £20‑£30.

Check the NHS prescription calculator for exact pricing, or ask your pharmacist about discount schemes. Some online pharmacies offer lower prices, but only when they ask for a prescription upload.

Common side effects and when to call a doctor

The most reported issues are nausea, dry mouth, headache and dizziness. Most of these settle after a few days. If you develop severe stomach pain, sweating, rapid heartbeat, or notice thoughts of self‑harm, seek medical help right away.

Other rarer reactions include liver problems (yellow skin or eyes) and increased blood pressure. Regular check‑ups let your doctor spot these early.

Interactions you should watch

Duloxetine can interact with other antidepressants, especially MAO inhibitors, and with some pain relievers like tramadol. Alcohol can make drowsiness worse. Always list every medication, supplement and over‑the‑counter product you take when you see a doctor.

If you’re switching from another SNRI or SSRI, your doctor may need a wash‑out period to avoid serotonin syndrome, a serious condition marked by agitation, fever and muscle rigidity.

Pregnancy, breastfeeding and special groups

Women who are pregnant or planning to become pregnant should discuss risks with their GP. Duloxetine crosses the placenta and appears in breast milk, so alternatives may be recommended.

Elderly patients may need a lower starting dose because they process the drug slower. Adjustments help limit dizziness and falls.

Quick checklist before you order online

• Have a valid UK prescription ready to upload.
• Verify the pharmacy is MHRA‑registered.
• Compare generic vs. brand pricing.
• Review the pharmacy’s return and contact policy.
• Read the patient information leaflet for dosage and side‑effect warnings.

Following these steps keeps you safe and saves money. Duloxetine can be a valuable part of managing depression or chronic pain when used correctly. If anything feels off, reach out to your prescriber – they’re there to help you stay on track.